Sodium hydride → N'-[6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-isobutyl-3-methoxy-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]-N,N-dimethylimidoformamide

HRID 13844

反応式

HRID 13844 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]([N:15]([CH2:21][CH:22]([CH3:24])[CH3:23])[C:16](=[O:20])[CH2:17][O:18][CH3:19])[C:12]([C:25]#[N:26])=[CH:11][C:10]=1[C:27]1[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=1.ClC1C=CC=CC=1C1N=C(NCC(C)C)C(C#N)=CC=1C1C=CC(Cl)=CC=1.COCC(Cl)=O.[H-].[Na+].NC1C2[C:74](=NC(C3C=CC(Cl)=CC=3Cl)=C(C3C=CC(Cl)=CC=3)C=2)[N:73]([CH2:95]C(C)C)[C:72](=O)C=1OC>>[Cl:33][C:30]1[CH:29]=[CH:28][C:27]([C:10]2[CH:11]=[C:12]3[C:13](=[N:14][C:9]=2[C:3]2[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=2[Cl:1])[N:15]([CH2:21][CH:22]([CH3:24])[CH3:23])[C:16](=[O:20])[C:17]([O:18][CH3:19])=[C:25]3[N:26]=[CH:72][N:73]([CH3:95])[CH3:74])=[CH:32][CH:31]=1

参加物

6

反応物 5

HCID 24758Sodium hydrideHCID 96623Methoxyacetyl chlorideHCID 687150546-(2-Chlorophenyl)-5-(4-chlorophenyl)-2-(isobutylamino)pyridine-3-carbonitrileHCID 68716559N-(6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-3-cyanopyridin-2-yl)-N-isobutyl-2-methoxyacetamideHCID 687181664-amino-7-(2,4-dichlorophenyl)-6-(4-chlorophenyl)-1-isobutyl-3-methoxy-1,8-naphthyridin-2(1H)-one

生成物 1

HCID 11307475N'-[6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-isobutyl-3-methoxy-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]-N,N-dimethylimidoformamide

実験手順

N-(6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-3-cyanopyridin-2-yl)-N-isobutyl-2-methoxyacetamide (prepared by the reaction of the product of Step A EXAMPLE 27 with 2-methoxyacetyl chloride using the conditions of EXAMPLE 62 Step A) was reacted with NaH using the conditions of EXAMPLE 80 affording 4-amino-7-(2,4-dichlorophenyl)-6-(4-chlorophenyl)-1-isobutyl-3-methoxy-1,8-naphthyridin-2(1H)-one which was treated to the conditions of EXAMPLE 85 to afford the title compound (E/Z mixture of isomers). HPLC/MS: 557.0 (M+1), 558.9 (M+3); Rt=3.70 min.

後処理

  1. additionwas treated to the conditions of EXAMPLE 85

出典と根拠

ORDレコード
ord-8b124af1c4444294b795ae920a47e0fd
出典データセット
uspto-grants-2010_06
特許番号
US07728141B2

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