2-Chloroethanol → 2-[(1-methyl-1H-imidazol-2-yl)thio]ethan-1-ol

HRID 1384628ノート

反応式

HRID 1384628 の反応式
Cl[CH2:2][CH2:3][OH:4].[SH:5][C:6]1[N:7]([CH3:11])[CH:8]=[CH:9][N:10]=1>[OH-].[Na+]>[OH:4][CH2:3][CH2:2][S:5][C:6]1[N:7]([CH3:11])[CH:8]=[CH:9][N:10]=1

参加物

4

反応物 2

HCID 342-ChloroethanolHCID 178480602HCID 178480602、化合物

生成物 1

HCID 27748452-[(1-methyl-1H-imidazol-2-yl)thio]ethan-1-ol収率 82.2%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

反応条件

温度
100 °C

実験手順

2-Chloroethanol (3 g, 37 mmol) was added to a solution of 2-mercapto-1-methylimidazole (3.45 g, 30 mmol) in 2M aqueous sodium hydroxide solution (30 ml) and the mixture heated at 100° C. for 2 hours. The mixture was allowed to cool and extracted with ethyl acetate. The combined extracts were dried (MgSO4) and the solvent removed by evaporation to give 2-(2-hydroxyethylthio)-1-methylimidazole (3.9 g, 82%). 1H NMR Spectrum: (DMSOd6) 3.04(t, 2H); 3.30(s, 3H); 3.54(t, 2H); 5.00(s, 1H); 6.87(s, 1H); 7.20(s, 1H)

後処理

  1. temperatureto cool
  2. extractionextracted with ethyl acetate
  3. dry with materialThe combined extracts were dried (MgSO4)
  4. customthe solvent removed by evaporation

出典と根拠

ORDレコード
ord-ee8cccb3e1e84cc098673571127cec83
出典データセット
uspto-grants-2001_07
特許番号
US06258951B1

反応ノート

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