8-Methylquinoline-5-carboxylic acid → 8-Methyl-1,2,3,4-tetrahydroquinoline-5-carboxylic acid

HRID 1385044ノート

反応式

HRID 1385044 の反応式
[CH3:1][C:2]1[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1.[H][H]>C(O)C.[Pd]>[CH3:1][C:2]1[C:11]2[NH:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 129507838-Methylquinoline-5-carboxylic acidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 139517338-Methyl-1,2,3,4-tetrahydroquinoline-5-carboxylic acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

0.1 mol of 8-methylquinoline-5-carboxylic acid was suspended in 1.5 l of ethanol and admixed with 10.0 g of palladium on activated carbon (5%). Over a period of 48 hours, the mixture was reduced in an autoclave at 50° C. using hydrogen (1 bar) (HPLC control). The reaction mixture was then filtered, the filter cake was washed with ethanol and the combined organic filtrates were concentrated.

後処理

  1. customwas reduced in an autoclave at 50° C.
  2. filtrationThe reaction mixture was then filtered
  3. washthe filter cake was washed with ethanol
  4. concentrationthe combined organic filtrates were concentrated

出典と根拠

ORDレコード
ord-d95a369dc23b41f4a78cbb3cc939dca0
出典データセット
uspto-grants-2001_07
特許番号
US06262074B1

反応ノート

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