HCID 53979019、化合物 → HCID 21183687、化合物
反応式
C([O:3][C:4](=[O:26])[CH2:5][CH2:6][NH:7][C:8]([C:10]1[CH:18]=[C:17]2[C:13]([C:14]([CH2:24][CH3:25])=[N:15][N:16]2[CH:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[CH:12][CH:11]=1)=[O:9])C>C(O)C.[OH-].[Na+]>[CH:19]1([N:16]2[C:17]3[C:13](=[CH:12][CH:11]=[C:10]([C:8]([NH:7][CH2:6][CH2:5][C:4]([OH:26])=[O:3])=[O:9])[CH:18]=3)[C:14]([CH2:24][CH3:25])=[N:15]2)[CH2:20][CH2:21][CH2:22][CH2:23]1参加物
4
実験手順
A mixture of 330 mg (0.923 mmol, 1.0 equiv) 3-[(1-cyclopentyl-3-ethyl-1H-indazole-6-carbonyl)-amino]-propionic acid ethyl ester in 10 mL ethanol and 4 mL 1N NaOH was heated to reflux for 1 h. After cooling to room temperature, the reaction mixture was concentrated, diluted with 75 mL H2O, acidified to pH 1, and extracted 3×35 mL ethyl acetate. The organic extracts were combined, washed 1×25 mL H2O, 1×25 mL brine, and dried over Na2SO4. Filtration, concentration of filtrate on a rotary evaporator and drying at high vacuum, room temperature gave 297 mg (98%) of white solid: mp 151-153° C.; Anal. calcd for C18H23N3O3: C, 65.63; H, 7.04; N, 12.76. Found: C, 65.75; H, 7.12; N, 12.91.