HCID 53875714、化合物 → HCID 86757151、化合物
反応式
C([O:8][NH:9][C:10]([CH2:12][CH2:13][NH:14][C:15]([C:17]1[CH:25]=[C:24]2[C:20]([C:21]([CH2:31][CH3:32])=[N:22][N:23]2[CH:26]2[CH2:30][CH2:29][CH2:28][CH2:27]2)=[CH:19][CH:18]=1)=[O:16])=[O:11])C1C=CC=CC=1>[OH-].[OH-].[Pd+2]>[OH:8][NH:9][C:10]([CH2:12][CH2:13][NH:14][C:15]([C:17]1[CH:25]=[C:24]2[C:20]([C:21]([CH2:31][CH3:32])=[N:22][N:23]2[CH:26]2[CH2:30][CH2:29][CH2:28][CH2:27]2)=[CH:19][CH:18]=1)=[O:16])=[O:11]参加物
3
実験手順
This compound was prepared according to the method of Example 38, using 203 mg (0.467 mmol, 1.0 equiv) 1-cyclopentyl-3-ethyl-1H-indazole-6-carboxylic acid (2-benzyloxycarbamoyl-ethyl)-amide as starting material and 50 mg of Pd(OH)2/C (Pearlman's catalyst) as catalyst, to give 147 mg (91%) of a white powder: mp 166-169° C.; Anal. calcd for C18H24N4O3: C, 62.77;H, 7.02; N, 16.27. Found: C, 62.58; H, 7.12; N, 16.27.
後処理
- customThis compound was prepared