Hydrochloric Acid → 2,2-dibromo-1-methylcyclopropanecarboxylic acid

To 25 mL of a 50:50 mixture of tetrahydrofuran/water was added 2,2-dibromo-1-methylcyclopropanecarboxylic acid, methyl ester(2.72 g, 10 mmol)and lithium hydroxide (0.8 g, 20 mmol). The reaction mixture was stirred overnight. The reaction mixture was acidified with 1 M hydrochloric acid (24 mL). The reaction mixture was extracted with dichloromethane (2×25 mL) and the organic phases were collected, washed with brine, dried (MgSO4)and evaporated to give the title product (16 g) as white crystals mp 108-109° C.

1. extractionThe reaction mixture was extracted with dichloromethane (2×25 mL)
2. customthe organic phases were collected
3. washwashed with brine, dried (MgSO4)and
4. customevaporated

ORDレコード

ord-7520ee281714406bb0cc9ab783c962e9

出典データセット

uspto-grants-2001_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06262099B1