(R)-2-[2-(4-methyl-piperidin-1-yl)ethyl]pyrrolidine-1-carboxylic acid, tert-butyl ester → HCID 54041338、化合物

HRID 1386022ノート

反応式

HRID 1386022 の反応式
[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][C@H:10]2[CH2:14][CH2:13][CH2:12][N:11]2C(OC(C)(C)C)=O)[CH2:4][CH2:3]1>FC(F)(F)C(O)=O.ClCCl>[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][C@H:10]2[CH2:14][CH2:13][CH2:12][NH:11]2)[CH2:4][CH2:3]1

参加物

4

反応物 1

HCID 10709075(R)-2-[2-(4-methyl-piperidin-1-yl)ethyl]pyrrolidine-1-carboxylic acid, tert-butyl ester

生成物 1

HCID 54041338HCID 54041338、化合物収率 101.9%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of the protected amine, (R)-2-[2-(4-methyl-piperidin-1-yl)ethyl ]pyrrolidine-1-carboxylic acid, tert-butyl ester (D5) (3.0 g, 10 mmol) in trifluoroacetic acid (15 ml) and dichloromethane (50 ml) was heated to reflux for 18 hours. The reaction mixture was concentrated and the residue partitioned between CH2Cl2 and sat. aqueous K2CO3. The organic phase was dried and concentrated to afford the title compound (2.0 g, q) MH+ 197.

後処理

  1. temperatureto reflux for 18 hours
  2. concentrationThe reaction mixture was concentrated
  3. customthe residue partitioned between CH2Cl2 and sat. aqueous K2CO3
  4. customThe organic phase was dried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-6d766e5fd2214577a1c990c70076b4fe
出典データセット
uspto-grants-2001_07
特許番号
US06265408B1

反応ノート

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