1-Naphthalenesulfonyl chloride → HCID 10249573、化合物

HRID 1386026ノート

反応式

HRID 1386026 の反応式
[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][C@H:10]2[CH2:14][CH2:13][CH2:12][NH:11]2)[CH2:4][CH2:3]1.C(N(C(C)C)CC)(C)C.[C:24]1([S:34](Cl)(=[O:36])=[O:35])[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:27]=[CH:26][CH:25]=1>ClCCl>[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][C@H:10]2[CH2:14][CH2:13][CH2:12][N:11]2[S:34]([C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH:27]=[CH:26][CH:25]=2)(=[O:36])=[O:35])[CH2:4][CH2:3]1

参加物

5

反応物 3

HCID 665601-Naphthalenesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 54041338HCID 54041338、化合物

生成物 1

HCID 10249573HCID 10249573、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (R)-2-[2-(4-Methyl-piperidin-1-yl)ethyl]pyrrolidine (D6) 1 mmol and -diisopropylethylamine (1 mmol) in dichloromethane (10 mL) at 0° C. was added 1-naphthalene sulfonyl chloride. Stirring was continued at room temp. for 12 hours. The solution was washed with 10% aqueous NaOH and brine, dried and concentrated. The residue was purified by chromatography on silica gel to afford the title compound (MH30 387).

後処理

  1. washThe solution was washed with 10% aqueous NaOH and brine
  2. customdried
  3. concentrationconcentrated
  4. customThe residue was purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-b50aac176ccd4315b59839b06ce998ba
出典データセット
uspto-grants-2001_07
特許番号
US06265408B1

反応ノート

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