2-Fluoro-5-(hydroxymethyl)benzonitrile → 2-Fluoro-5-formylbenzonitrile

HRID 1386050ノート

反応式

HRID 1386050 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[F:11])[CH2:6][OH:7])#[N:2]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[C:1]([C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[F:11])[CH:6]=[O:7])#[N:2]

参加物

4

反応物 1

HCID 27739342-Fluoro-5-(hydroxymethyl)benzonitrile

生成物 1

HCID 27695822-Fluoro-5-formylbenzonitrile収率 54.2%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

A solution of the product from Example 82B (0.40 g, 2.6 mmol) in chloroform (50 mL) was treated with manganese dioxide (0.55 g, 7.8 mmol), stirred at room temperature overnight, filtered, solvent evaporated and the residue flash chromatographed over silica gel eluting with ethyl acetate:hexane (1:1) to provide 0.21 g 3-cyano-4-fluorobenzaldehyde.

後処理

  1. filtrationfiltered
  2. customsolvent evaporated
  3. customthe residue flash chromatographed over silica gel eluting with ethyl acetate:hexane (1:1)

出典と根拠

ORDレコード
ord-eca09c83a5364db3b29d773169eb1b7d
出典データセット
uspto-grants-2001_07
特許番号
US06265417B1

反応ノート

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