Water → 4-(3-Methoxy-4-methylphenyl)butanoic acid

HRID 1386406ノート

反応式

HRID 1386406 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:10][CH2:11][CH2:12][C:13]#N)[CH:6]=[CH:7][C:8]=1[CH3:9].[OH-:15].[Na+].[OH2:17]>CCO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:10][CH2:11][CH2:12][C:13]([OH:17])=[O:15])[CH:6]=[CH:7][C:8]=1[CH3:9]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 186265273-(3-Methoxy-4-methylphenyl)propyl cyanide

生成物 1

HCID 186264724-(3-Methoxy-4-methylphenyl)butanoic acid収率 75.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 6.75 g (35.7 mmol) of 3-(3-methoxy-4-methylphenyl)propyl cyanide in 75 mL of EtOH was treated with a solution of 8.0 g (0.2 mol) of NaOH in 40 mL of H2O and heated at reflux overnight. The solvent was removed under reduced pressure and the residue taken up in H2O. After washing with Et2O, the aqueous solution was acidified to the Congo Red end point with dilute HCl. A white solid separated which was collected and dried. There was obtained 5.6 g (75.5% yield) of the product, mp 69-70° C. The structure was confirmed by NMR and mass spectroscopy. MS m/z 209 (M+H+).

後処理

  1. temperatureheated
  2. temperatureat reflux overnight
  3. customThe solvent was removed under reduced pressure
  4. washAfter washing with Et2O
  5. customA white solid separated which
  6. customwas collected
  7. customdried

出典と根拠

ORDレコード
ord-41898323efae4b798a4462ae9490b4ad
出典データセット
uspto-grants-2001_07
特許番号
US06265422B1

反応ノート

読み込み中…