HCID 21182006、化合物 → HCID 21182005、化合物
反応式
[CH3:1][C:2]1[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[C:3]=1[O:4][CH2:5][CH2:6][N:7]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=1)[CH3:8]>C(O)(C)C.[Pd]>[CH3:1][C:2]1[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[C:3]=1[O:4][CH2:5][CH2:6][N:7]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=1)[CH3:8]参加物
4
実験手順
A solution containing 0.40 g (1.23 mmol) of N-[2-(2,6-dimethylphenoxy)ethyl]-N-methyl-2-(4-nitrophenyl)ethylamine (Example 2) in 7 ml of isopropanol is added to a suspension of 0.1 g of 10% palladium-on-carbon catalyst in 7 ml of isopropanol. The suspension is hydrogenated under atmospheric pressure. After completion of the reaction, the catalyst is filtered and washed with isopropanol. The filtrate is evaporated to constant weight under reduced pressure to obtain 0.37 g of the oily base (76%), Rf=0.35 (ethyl acetate/methanol=9:1).