Potassium Carbonate → HCID 53804942、化合物

HRID 1386829

反応式

HRID 1386829 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[N:13][O:14][C:15]=2[CH3:16])=[O:10])=[CH:4][CH:3]=1.[I:17][CH2:18][CH2:19][CH2:20]I.C(=O)([O-])[O-].[K+].[K+]>>[I:17][CH2:18][CH2:19][CH2:20][O:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[N:13][O:14][C:15]=2[CH3:16])=[O:10])=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 11430Potassium CarbonateHCID 123141,3-DiiodopropaneHCID 19439747N-(4-Hydroxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide

生成物 1

HCID 53804942HCID 53804942、化合物

実験手順

6.5 g (0.03 mol) of 5-methylisoxazole-4-carboxylic acid (4-hydroxyphenyl)amide are dissolved in 57 ml (0.5 mol) of 1,3-diiodopropane and 26.2 g (0.19 mol) of finely ground potassium carbonate are added with intensive stirring. The reaction is complete after approximately 4 h. Working up is carried out by means of filtration, concentration and chromatography on silica gel by means of ethyl acetate/petroleum ether 1:1 with addition of 1% glacial acetic acid. The yield of the process was 6.7 g.

後処理

  1. filtrationWorking up is carried out by means of filtration, concentration and chromatography on silica gel by means of ethyl acetate/petroleum ether 1:1 with addition of 1% glacial acetic acid

出典と根拠

ORDレコード
ord-5e2b4484594241b88abc525754992300
出典データセット
uspto-grants-2001_07
特許番号
US06265588B1

関連ノート

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