Formaldehyde → N-methyl-N-(phosphonomethyl)glycine

HRID 1386870ノート

反応式

HRID 1386870 の反応式
[C:1]([N:4]([CH2:6][C:7]([OH:9])=[O:8])[CH3:5])(=O)C.[P:10]([OH:13])([OH:12])[OH:11].S(=O)(=O)(O)O.C=O>O>[P:10]([CH2:1][N:4]([CH3:5])[CH2:6][C:7]([OH:9])=[O:8])([OH:13])([OH:12])=[O:11]

参加物

6

反応物 4

HCID 712FormaldehydeHCID 1118Sulfuric AcidHCID 107909Phosphorous acidHCID 10975514N-Acetyl-N-methylglycine

生成物 1

HCID 541499N-methyl-N-(phosphonomethyl)glycine収率 98%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
120 °C

実験手順

N-acetyl sarcosine (XX)(2.0 g, 15.3 mmole), phosphorous acid (1.25 g, 15.3 mmole) were mixed with concentrated sulfuric acid (3.1 g) and water (1.7 g) then refluxed in a 120° C. oil bath. Formalin, 37% (1.4 g, 16.7 mmole) was added dropwise over 20 min. and the reaction was continued for an additional 18 h. 31P NMR analysis indicated 98% yield of (XXI) based on mmoles of (XX) charged.

出典と根拠

ORDレコード
ord-049a1b8f4b8f4164914ad0e6f4799313
出典データセット
uspto-grants-2001_07
特許番号
US06265605B1

反応ノート

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