Propofol → 2,6-Diisopropylanisole
反応式
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:12])[CH3:11])[C:5]=1[OH:13])([CH3:3])[CH3:2].[C:14](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[CH:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5]=1[O:13][CH3:14])([CH3:12])[CH3:11]参加物
5
実験手順
A mixture of 2,6-diisopropyl phenol (20 g, 0.11 mol), potassium carbonate (62 g, 0.45 mol), acetone (160 ml) and methyl iodide (28 ml, 0.45 mole) is refluxed for three days. The reaction mixture is filtered through celite, evaporated, dissolved in ether, washed twice with 1M sodium hydroxide, dried over magnesium sulphate and concentrated to afford 15.1 g (0.08 mol, 70%) of 2,6-diisopropyl anisole as a slightly yellow oil.
後処理
- temperatureis refluxed for three days
- filtrationThe reaction mixture is filtered through celite
- customevaporated
- dissolutiondissolved in ether
- washwashed twice with 1M sodium hydroxide
- dry with materialdried over magnesium sulphate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-1f6add6f653b4925b9969c9eb58db831
- 出典データセット
- uspto-grants-2001_07
- 特許番号
- US06266622B1
反応ノート
読み込み中…