Pyrrolidine → Methyl 5-[(1-Pyrrolidinyl)methyl]pyrazine-2-carboxylate

HRID 1387079

反応式

HRID 1387079 の反応式
Br[CH2:2][C:3]1[N:4]=[CH:5][C:6]([C:9]([O:11][CH3:12])=[O:10])=[N:7][CH:8]=1.[NH:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1>>[N:13]1([CH2:2][C:3]2[N:4]=[CH:5][C:6]([C:9]([O:11][CH3:12])=[O:10])=[N:7][CH:8]=2)[CH2:17][CH2:16][CH2:15][CH2:14]1

参加物

3

反応物 2

HCID 31268PyrrolidineHCID 21973569Methyl 5-(bromomethyl)pyrazine-2-carboxylate

生成物 1

HCID 21182947Methyl 5-[(1-Pyrrolidinyl)methyl]pyrazine-2-carboxylate収率 85%

実験手順

By essentially following the procedure used to prepare Example 137, Part B, the title compound was prepared from methyl 5-(bromomethyl)pyrazine-2-carboxylate (Part A) and pyrrolidine in 85% yield as a pale yellow oil. The mixture was subjected to flash chromatography on silica gel, eluting with a gradient of EtOAc(100-95%)/Et3N(0-5%).

後処理

  1. customto prepare Example 137, Part B
  2. washeluting with a gradient of EtOAc(100-95%)/Et3N(0-5%)

出典と根拠

ORDレコード
ord-1dbb9e58ce5643789400c3725d81030e
出典データセット
uspto-grants-2001_07
特許番号
US06265575B1

関連ノート

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