Hydrochloric Acid → 2-[4-(Dimethylamino)phenyl]-2-methylpropanoic acid

HRID 1387298ノート

反応式

HRID 1387298 の反応式
[CH3:1][N:2]([CH3:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]([CH3:16])([CH3:15])[C:10]([O:12]CC)=[O:11])=[CH:5][CH:4]=1.[OH-].[Na+].Cl>C(O)C.O>[CH3:17][N:2]([CH3:1])[C:3]1[CH:4]=[CH:5][C:6]([C:9]([CH3:15])([CH3:16])[C:10]([OH:12])=[O:11])=[CH:7][CH:8]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57182128HCID 57182128、化合物

生成物 1

HCID 206960032-[4-(Dimethylamino)phenyl]-2-methylpropanoic acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A mixture of ethyl (4-dimethylaminophenyl)-2,2-dimethylacetate (1.00 g, 4.25 mmol) and sodium hydroxide (0.85 g) in ethanol (20 mL) and water (9 mL) was heated under reflux for 18 hours. The mixture was cooled, acidified with 10% HCl, and washed with ethyl acetate. The aqueous phase was evaporated. The residue was dissolved in aqueous saturated sodium bicarbonate, and extracted with ethyl acetate. Tile organic phase was dried, filtered and evaporated to give (4-dimethylaminophenyl)-2,2-dimethylacetic acid as a faint red solid (0.81 0. 92%).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. temperatureThe mixture was cooled
  4. washwashed with ethyl acetate
  5. customThe aqueous phase was evaporated
  6. dissolutionThe residue was dissolved in aqueous saturated sodium bicarbonate
  7. extractionextracted with ethyl acetate
  8. customTile organic phase was dried
  9. filtrationfiltered
  10. customevaporated

出典と根拠

ORDレコード
ord-4dc821c86928442195cd19229079c3fe
出典データセット
uspto-grants-2001_07
特許番号
US06268365B1

反応ノート

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