1-Methylpiperazine → HCID 3071002、化合物
反応式
[CH2:1]([O:4][CH2:5][CH2:6][N:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1Cl)[CH:2]=[CH2:3].[CH3:17][N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1.C(O)(=O)/C=C/C(O)=O>>[CH2:1]([O:4][CH2:5][CH2:6][N:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[N:21]1[CH2:22][CH2:23][N:18]([CH3:17])[CH2:19][CH2:20]1)[CH:2]=[CH2:3]参加物
4
実験手順
In the same manner as described in Example 1 using 1-[2-(allyloxy)ethyl]-2-chlorobenzimidazole (3.00 g), N-methylpiperazine (3.00 g) and fumaric acid (2.16 g), there are obtained crude crystals, which are recrystallized from ethyl acetate-ethanol to give 1-[2-(allyloxy)ethyl]-2-(4-methyl-1-piperazinyl)benzimidazole.3/2 fumarate (3.18 g) as colorless plates, m.p. 161.5°-164° C.
後処理
- customare obtained crude crystals, which
- customare recrystallized from ethyl acetate-ethanol