p-Toluenesulfonic acid → HCID 13869332、化合物
反応式
[CH3:1][C:2]1[S:6][C:5]([S:7](=[O:10])(=[O:9])[NH2:8])=[C:4]([C:11]([OH:13])=O)[CH:3]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[CH3:1][C:2]1[S:6][C:5]2[S:7](=[O:10])(=[O:9])[NH:8][C:11](=[O:13])[C:4]=2[CH:3]=1参加物
4
実験手順
A mixture of 0.1 gm (0.45 millimols) of 5-methyl-2-sulfamoyl-thiophene-3-carboxylic acid, 50 ml of anhydrous toluene and 5 mgm of p-toluene-sulfonic acid was heated for 10 hours in a vessel equipped with a water trap. The reaction mixture was evaporated to dryness in vacuo and separated by column chromatography. 0.40 mgm (49% of theory) of 5-methyl-thieno[3,2-d]isothiazole-3(2H)-one-1, 1-dioxide were obtained.
後処理
- temperaturewas heated for 10 hours in a vessel
- customequipped with a water trap
- customThe reaction mixture was evaporated to dryness in vacuo
- customseparated by column chromatography
出典と根拠
- ORDレコード
- ord-7c77e99adfce41a3b143454b120a75b1
- 出典データセット
- uspto-grants-1984_02
- 特許番号
- US04430355
反応ノート
読み込み中…