Water → 2-(4-Methylphenyl)quinazolin-4(3H)-one

HRID 1388236ノート

反応式

HRID 1388236 の反応式
[C:1]([C:4]1[CH:19]=[CH:18][CH:17]=[CH:16][C:5]=1[NH:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1)=O)(=[O:3])[NH2:2].[OH-].[Na+].O>C(O)(=O)C>[CH3:15][C:12]1[CH:13]=[CH:14][C:9]([C:7]2[NH:2][C:1](=[O:3])[C:4]3[C:5](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:6]=2)=[CH:10][CH:11]=1

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 8196472-[(4-methylbenzoyl)amino]benzamide

生成物 1

HCID 1354521092-(4-Methylphenyl)quinazolin-4(3H)-one

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 2'-carbamoyl-p-toluanilide (66.97 g; 0.263 mol), sodium hydroxide (41.9 g) and water 837 ml) is stirred and heated at reflux for 0.5 hour. The resultant solution is cooled down, made acid with acetic acid. The reaction mixture is filtered, the isolated product is washed and dried to afford 58.16 g off white solid, mp 239°-241° C. Recrystallized from absolute ethanol, the product has a mp of 239°-240.5° C.

後処理

  1. temperatureheated
  2. temperatureat reflux for 0.5 hour
  3. filtrationThe reaction mixture is filtered
  4. washthe isolated product is washed
  5. customdried
  6. customto afford 58.16 g off white solid, mp 239°-241° C
  7. customRecrystallized from absolute ethanol

出典と根拠

ORDレコード
ord-f041c9964c7241bf930d40ac3ff617ab
出典データセット
uspto-grants-1984_02
特許番号
US04431440

反応ノート

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