1,3-Dichloroacetone → 4-(Chloromethyl)-2-(3,4-dichlorophenyl)-1,3-thiazole

HRID 1388302ノート

反応式

HRID 1388302 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[C:5]([NH2:7])=[S:6].[Cl:12][CH2:13][C:14]([CH2:16]Cl)=O>CC(C)=O>[Cl:12][CH2:13][C:14]1[N:7]=[C:5]([C:4]2[CH:8]=[CH:9][C:10]([Cl:11])=[C:2]([Cl:1])[CH:3]=2)[S:6][CH:16]=1

参加物

4

反応物 2

HCID 107931,3-DichloroacetoneHCID 20608953,4-Dichlorothiobenzamide

生成物 1

HCID 131863604-(Chloromethyl)-2-(3,4-dichlorophenyl)-1,3-thiazole

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 3,4-dichlorothiobenzamide (8.24 g., 0.04 mol), 1,3-dichloroacetone (5.1 g., 0.04 mol) in acetone (150 ml) was stirred at room temperature overnight. After evaporation of the acetone under reduced pressure, the residue was dissolved in methanol (150 ml) and the solution refluxed 11/2 hours. After cooling and removal of the methanol, the residue was slurried with a small quantity of methanol. The solids which formed after filtration showed m.p. 93°-96° C. (6.05 g.).

後処理

  1. customAfter evaporation of the acetone under reduced pressure
  2. dissolutionthe residue was dissolved in methanol (150 ml)
  3. temperaturethe solution refluxed 11/2 hours
  4. temperatureAfter cooling
  5. customremoval of the methanol
  6. customThe solids which formed
  7. filtrationafter filtration

出典と根拠

ORDレコード
ord-b4c7d1242fc44590aa78f89654b9bfb5
出典データセット
uspto-grants-1984_02
特許番号
US04431652

反応ノート

読み込み中…