Barium → 4-(1H-Imidazol-2-yl)-pyridine

HRID 1388380ノート

反応式

HRID 1388380 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[NH:8][CH2:9][CH2:10][N:11]=2)=[CH:3][CH:2]=1.[Ba]>C(Cl)Cl>[NH:8]1[CH:9]=[CH:10][N:11]=[C:7]1[C:4]1[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=1

参加物

4

反応物 2

HCID 5355457BariumHCID 111593874-(4,5-dihydro-1H-imidazol-2-yl)pyridine

生成物 1

HCID 3168174-(1H-Imidazol-2-yl)-pyridine収率 68.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-(4-pyridyl)-imidazoline (7.0 g, 0.047 M) and barium mangnate (52.5 g) in CH2Cl2 (500 ml) were refluxed with stirring for 24 hrs. The reaction mixture was then filtered through diatomaceous earth, washed with methylene chloride and then ethylacetate. The combined filtrates were concentrated and crystallized from ethylacetate-petroleum ether to give 4-(1H-imidazol-2-yl)pyridine (4.7 g, 67% yield).

後処理

  1. filtrationThe reaction mixture was then filtered through diatomaceous earth
  2. washwashed with methylene chloride
  3. concentrationThe combined filtrates were concentrated
  4. customcrystallized from ethylacetate-petroleum ether

出典と根拠

ORDレコード
ord-176e8998b12847ccaf529f5389d6b725
出典データセット
uspto-grants-1984_02
特許番号
US04431653

反応ノート

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