N-[2-(4-Benzoyloxyphenyl)-1-methylethyl]-2-(2-benzofuranyl)-2-hydroxyethanamine → N-[2-(4-Hydroxyphenyl)-1-methylethyl]-2-(2-benzofuranyl)-2-hydroxyethanamine

HRID 1388741ノート

反応式

HRID 1388741 の反応式
C([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH:17]([NH:19][CH2:20][CH:21]([C:23]2[O:24][C:25]3[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=3[CH:27]=2)[OH:22])[CH3:18])=[CH:12][CH:11]=1)(=O)C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.[Pd]>[OH:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:16][CH:17]([NH:19][CH2:20][CH:21]([C:23]2[O:24][C:25]3[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=3[CH:27]=2)[OH:22])[CH3:18])=[CH:14][CH:15]=1

参加物

5

反応物 2

HCID 20470050N-[2-(4-Benzoyloxyphenyl)-1-methylethyl]-2-(2-benzofuranyl)-2-hydroxyethanamineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 12816512N-[2-(4-Hydroxyphenyl)-1-methylethyl]-2-(2-benzofuranyl)-2-hydroxyethanamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

N-[2-(4-Benzoyloxyphenyl)-1-methylethyl]-2-(2-benzofuranyl)-2-hydroxyethanamine (2 g) in ethyl acetate (150 ml) was hydrogenated over 5% palladium on charcoal at atmospheric pressure. After uptake of hydrogen had ceased the mixture was filtered and the filtrate evaporated to dryness. Chromatography of the residual oil on Kieselgel 60 (5% methanol in dichloromethane) gave the title compound, m.p. 135°-8°, (EtOAc-ether), as a 94:6 mixture of diastereoisomers.

後処理

  1. filtrationwas filtered
  2. customthe filtrate evaporated to dryness

出典と根拠

ORDレコード
ord-ca4e6b2e91d245f797dad6261c1c3021
出典データセット
uspto-grants-1984_02
特許番号
US04432993

反応ノート

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