Diazomethane → Ethyl 4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate

HRID 1388930

反応式

HRID 1388930 の反応式
[OH:1][C:2]1[C:3]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:4]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[N:5]([CH3:7])[CH:6]=1.[N+](=[CH2:21])=[N-].CN(N=O)C(N)=O.[OH-].[K+]>C(OCC)C>[CH3:21][O:1][C:2]1[C:3]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:4]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[N:5]([CH3:7])[CH:6]=1

参加物

6

反応物 4

HCID 9550DiazomethaneHCID 12699N-Methyl-N-nitrosoureaHCID 14797Potassium HydroxideHCID 13345719Ethyl 3-ethoxycarbonyl-4-hydroxy-1-methylpyrrole-2-acetate

生成物 1

HCID 20469092Ethyl 4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Ethyl 4-hydroxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate (20 mmole) is dissolved in 10 μl of diethyl ether containing diazomethane freshly prepared from N-methyl-N-nitrosourea and potassium hydroxide. After the reaction is allowed to stand at room temperature for about 0.5 hour, the ether is evaporated under reduced pressure at mild temperature and the residue, i.e., crude ethyl-4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate, is used in the next step without further purification.

後処理

  1. customthe ether is evaporated under reduced pressure at mild temperature
  2. customthe residue, i.e., crude ethyl-4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate, is used in the next step without further purification

出典と根拠

ORDレコード
ord-195bafe7bb434b3881f51fa3bf30cad8
出典データセット
uspto-grants-1984_02
特許番号
US04434175

関連ノート

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