Sodium Hydroxide → 4-(Phenoxymethyl)piperidine
反応式
C([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:11][CH2:10]1)(=O)C1C=CC=CC=1.[OH-].[Na+]>C(O)C>[O:16]([CH2:15][CH:12]1[CH2:11][CH2:10][NH:9][CH2:14][CH2:13]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1参加物
4
実験手順
A mixture of 22.0 g (0.075 mole) of N-benzoyl-4-phenoxymethylpiperidine, 25 ml of 10 N aqueous sodium hydroxide solution and 175 ml of ethanol is heated under reflux for 18 hours. The reaction mixture is then evaporated in a vacuum and the residue is taken up in diethyl ether, washed with water, dried over anhydrous sodium sulfate and the solvent then evaporated off. There are obtained 12.0 g of 4-phenoxymethylpiperidine (84% of theory); m.p. 42°-43° C.
後処理
- temperatureis heated
- temperatureunder reflux for 18 hours
- customThe reaction mixture is then evaporated in a vacuum
- washwashed with water
- dry with materialdried over anhydrous sodium sulfate
- customthe solvent then evaporated off
出典と根拠
- ORDレコード
- ord-bf591f6cad124df6acc97ecd3a066dcc
- 出典データセット
- uspto-grants-1981_01
- 特許番号
- US04243807
反応ノート
読み込み中…