Thionyl Chloride → (4-Fluorophenylthio)acetyl chloride
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][C:10]([OH:12])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:15])=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][C:10]([Cl:15])=[O:12])=[CH:4][CH:3]=1参加物
3
実験手順
A mixture of 5.3 g of (4-fluorophenylthio)acetic acid and 6.8 g of thionyl chloride is refluxed for 2 hours. Excess of thionyl chloride is evaporated in vacuo and the residue distilled. There are obtained 5.1 g (88%) of oily (4-fluorophenylthio)acetyl chloride, b.p. 76°-77° C./0.25 Torr.
後処理
- temperatureis refluxed for 2 hours
- customExcess of thionyl chloride is evaporated in vacuo
- distillationthe residue distilled
出典と根拠
- ORDレコード
- ord-490eada3ec7f42a4a9a4961ce81a8b3d
- 出典データセット
- uspto-grants-1981_01
- 特許番号
- US04243805
反応ノート
読み込み中…