Succinic anhydride → HCID 70542119、化合物

HRID 1389673ノート

反応式

HRID 1389673 の反応式
C(N(CC)CC)C.[S:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[CH2:13][C:14]([NH:16][C@@H:17]1[C:29](=[O:30])[N:19]2[C:20]([C:26]([OH:28])=[O:27])=[C:21]([CH2:24][OH:25])[CH2:22][S:23][C@H:18]12)=[O:15].[C:31]1(=[O:37])[O:36][C:34](=[O:35])[CH2:33][CH2:32]1>ClCCl>[S:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[CH2:13][C:14]([NH:16][C@@H:17]1[C:29](=[O:30])[N:19]2[C:20]([C:26]([OH:28])=[O:27])=[C:21]([CH2:24][O:25][C:31](=[O:37])[CH2:32][CH2:33][C:34]([OH:36])=[O:35])[CH2:22][S:23][C@H:18]12)=[O:15]

参加物

4

反応物 2

HCID 7922Succinic anhydrideHCID 70542398HCID 70542398、化合物

生成物 1

HCID 70542119HCID 70542119、化合物収率 88.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In dichloromethane (30 ml) was dissolved 7β-(2-thienylacetamido)-3-hydroxymethyl-3-cephem-4-carboxylic acid triethylamine salt (4.55 g), followed by the addition of succinic anhydride (1.50 g). The mixture was stirred at room temperature for 2 hours. The dichloromethane was distilled off and, following the addition of 3% aqueous phosphoric acid solution (100 ml), the residue was extracted with ethyl acetate (150 ml). The ethyl acetate layer was washed with a saturated aqueous solution of sodium chloride (100 ml×2), dried (over magnesium sulfate) and concentrated under reduced pressure. The residue was treated with ether and the resultant powder was recovered by filtration, washed with ether and dried under reduced pressure over phosphorus pentoxide. The procedure provided 7β-(2-thienylacetamido)-3-(3-carboxypropionyloxy)methyl-3-cephem-4-carboxylic acid (4.00 g).

後処理

  1. distillationThe dichloromethane was distilled off
  2. additionthe addition of 3% aqueous phosphoric acid solution (100 ml)
  3. extractionthe residue was extracted with ethyl acetate (150 ml)
  4. washThe ethyl acetate layer was washed with a saturated aqueous solution of sodium chloride (100 ml×2)
  5. dry with materialdried (over magnesium sulfate)
  6. concentrationconcentrated under reduced pressure
  7. additionThe residue was treated with ether
  8. filtrationthe resultant powder was recovered by filtration
  9. washwashed with ether
  10. dry with materialdried under reduced pressure over phosphorus pentoxide

出典と根拠

ORDレコード
ord-4f1b2c0d7f6f4c4b9ff08b9ef4b31b7c
出典データセット
uspto-grants-1981_01
特許番号
US04245088

反応ノート

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