Hydrogen Bromide → HCID 23455899、化合物

HRID 1389748ノート

反応式

HRID 1389748 の反応式
C(OC([C:6]1[O:7][C:8]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([CH2:22][C:23]([O:25]CC)=[O:24])=[CH:18][CH:17]=3)=[CH:12][C:9]=2[C:10]=1[CH3:11])=O)C.Br>C(O)(=O)C>[CH3:11][C:10]1[C:9]2[CH:12]=[C:13]([C:16]3[CH:21]=[CH:20][C:19]([CH2:22][C:23]([OH:25])=[O:24])=[CH:18][CH:17]=3)[CH:14]=[CH:15][C:8]=2[O:7][CH:6]=1

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 12902869HCID 12902869、化合物

生成物 1

HCID 23455899HCID 23455899、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 17 g. of the product of step A in 100 ml. of acetic acid with 35 ml. of 48 percent hydrobromic acid is heated at reflux for three hours, then poured into ice water. This mixture is extracted into dichloromethane, and the extracts are dried to provide 4-(3-methylbenzofuran-5-yl)phenylacetic acid. This intermediate is esterified by heating with a trace of sulfuric acid in ethanol. The product is purified by chromatography on silica gel, eluting with 20 percent dichloromethane in carbon tetrachloride to provide ethyl 4-(3-methylbenzofuran-5-yl)phenylacetate.

後処理

  1. temperatureat reflux for three hours
  2. extractionThis mixture is extracted into dichloromethane
  3. customthe extracts are dried

出典と根拠

ORDレコード
ord-634561284d2b4510990fd0aa846d2779
出典データセット
uspto-grants-1981_01
特許番号
US04246179

反応ノート

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