Potassium Carbonate → N-Formyl-4-bromomethylpiperidine

HRID 1389769

反応式

HRID 1389769 の反応式
Br.[Br:2][CH2:3][CH:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.[C:10](=O)([O-])[O-:11].[K+].[K+]>O.C(OC)=O>[CH:10]([N:7]1[CH2:8][CH2:9][CH:4]([CH2:3][Br:2])[CH2:5][CH2:6]1)=[O:11]

参加物

5

反応物 2

HCID 11430Potassium CarbonateHCID 135032174-(Bromomethyl)piperidine hydrobromide

生成物 1

HCID 19812293N-Formyl-4-bromomethylpiperidine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 7865Methyl formate溶媒

実験手順

To a solution of 4-bromomethylpiperidin hydrobromide (12.8 g, 0.05 mole) in water (5 ml), methyl formate (25 ml) and potassium carbonate (10 g) were added and the mixture stirred for 20 hours. The solvent was decanted, and the residue was extracted with two 25 ml portions of ether. The combined organic phases were washed with water, dried and evaporated to give (A) as a colourless oil. The IR spectrum (chloroform) showed a strong band at 1650 cm-1.

後処理

  1. customThe solvent was decanted
  2. extractionthe residue was extracted with two 25 ml portions of ether
  3. washThe combined organic phases were washed with water
  4. customdried
  5. customevaporated

出典と根拠

ORDレコード
ord-54a83d9fc37c4287bd1bcfc5f8fc4ffa
出典データセット
uspto-grants-1981_01
特許番号
US04246262

関連ノート

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