Borane → 4-(Thiophen-2-yl)butan-1-ol

HRID 1389775ノート

反応式

HRID 1389775 の反応式
B.[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][CH2:8][CH2:9][C:10](O)=[O:11]>O1CCCC1>[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][CH2:8][CH2:9][CH2:10][OH:11]

参加物

4

反応物 2

HCID 6331BoraneHCID 783864-(2-Thienyl)Butyric Acid

生成物 1

HCID 126238624-(Thiophen-2-yl)butan-1-ol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To 240 ml. of 1 M borane in tetrahydrofuran chilled in an ice bath, is added dropwise, 20.4 g. of 4-(2-thienyl)-butyric acid in 50 ml. of tetrahydrofuran. After the addition, the mixture is allowed to stand at room temperature for 17 hours and is poured onto ice. After standing, the mixture is extracted with ether, the ether extract washed with water, dried over magnesium sulfate and concentrated in vacuo to give a pale yellow oil.

後処理

  1. additionis added dropwise
  2. additionAfter the addition
  3. additionis poured onto ice
  4. extractionthe mixture is extracted with ether
  5. extractionthe ether extract
  6. washwashed with water
  7. dry with materialdried over magnesium sulfate
  8. concentrationconcentrated in vacuo
  9. customto give a pale yellow oil

出典と根拠

ORDレコード
ord-e3e7215e1e6744f9994e5b7189bcf818
出典データセット
uspto-grants-1981_01
特許番号
US04246275

反応ノート

読み込み中…