Hydrogen Bromide → Fenbufen EP Impurity D

HRID 1389973

反応式

HRID 1389973 の反応式
OC1C=CC(C2C=CC(C3OC(=O)CC3)=CC=2)=CC=1.C[O:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][C:31]([C:34](=[O:40])[CH2:35][CH2:36][C:37]([OH:39])=[O:38])=[CH:30][CH:29]=2)=[CH:24][CH:23]=1.Br>>[OH:21][C:22]1[CH:23]=[CH:24][C:25]([C:28]2[CH:33]=[CH:32][C:31]([C:34](=[O:40])[CH2:35][CH2:36][C:37]([OH:39])=[O:38])=[CH:30][CH:29]=2)=[CH:26][CH:27]=1

参加物

4

反応物 3

HCID 260Hydrogen BromideHCID 20294315Dihydro-5-(4'-hydroxy-4-biphenylyl)-2(3H)-furanoneHCID 230052384-(4'-Methoxy-biphenyl-4-yl)-4-oxo-butyric acid

生成物 1

HCID 13930818Fenbufen EP Impurity D

実験手順

The compound Dihydro-5-(4'-hydroxy-4-biphenylyl)-2(3H)-furanone may be prepared by treating 4'-methoxy-γ-oxo-4-biphenylbutyric acid with hydrogen bromide in acid to produce 4'-hydroxy-γ-oxo-4-biphenylbutyric acid. This in turn is treated with sodium borohydride as described above and then purified with organic solvents to produce the desired product.

出典と根拠

ORDレコード
ord-c96a0bb6a0a24592a8b775bb9406c92a
出典データセット
uspto-grants-1981_01
特許番号
US04247466

関連ノート

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