Acetic Anhydride → N(2,5-DIME-PYRROL-1-YL)-6-($-MORPHOL)-3-PYRIDAZ-

HRID 1390006ノート

反応式

HRID 1390006 の反応式
[CH3:1][C:2]1[N:3]([NH:8][C:9]2[N:10]=[N:11][C:12]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[CH:13][CH:14]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22]>N1C=CC=CC=1>[C:21]([N:8]([N:3]1[C:4]([CH3:7])=[CH:5][CH:6]=[C:2]1[CH3:1])[C:9]1[N:10]=[N:11][C:12]([N:15]2[CH2:16][CH2:17][O:18][CH2:19][CH2:20]2)=[CH:13][CH:14]=1)(=[O:23])[CH3:22]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 711434-(6-((2,5-Dimethylpyrrol-1-yl)amino)-3-pyridazinyl)morpholine

生成物 1

HCID 23276131N(2,5-DIME-PYRROL-1-YL)-6-($-MORPHOL)-3-PYRIDAZ-

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
110 °C

実験手順

A mixture of 6 g (22 m mol) of N-(2,5-dimethyl-1H-pyrrol-yl)-6-morpholino-3-pyridazineamine, 30 ml of acetic anhydride, and 6 ml of pyridine is heated for one hour at 110° C. The reaction mixture is evaporated to dryness under vacuum and the oily residue is dissolved in 150 ml of ethyl acetate. The organic solution is washed first with 50 ml of an aqueous solution of sodium bicarbonate and then with 50 ml of water.

後処理

  1. customThe reaction mixture is evaporated to dryness under vacuum
  2. dissolutionthe oily residue is dissolved in 150 ml of ethyl acetate
  3. washThe organic solution is washed first with 50 ml of an aqueous solution of sodium bicarbonate

出典と根拠

ORDレコード
ord-77a61adbb99741d4b65194677054727a
出典データセット
uspto-grants-1981_01
特許番号
US04247551

反応ノート

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