Thionyl Chloride → N-(3',4'-Dichlorophenyl)-3,4-dimethyl-2-chloro-5-oxo-2,5-dihydropyrrole
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13](=[O:14])[C:12]([CH3:15])=[C:11]([CH3:16])[CH:10]2O)[CH:5]=[CH:6][C:7]=1[Cl:8].S(Cl)([Cl:20])=O>>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13](=[O:14])[C:12]([CH3:15])=[C:11]([CH3:16])[CH:10]2[Cl:20])[CH:5]=[CH:6][C:7]=1[Cl:8]参加物
3
実験手順
27.2 g of N-(3',4'-dichlorophenyl)-3,4-dimethyl-2-hydroxy-5-oxo-2,5-dihydropyrrole (see Example 3) is added to 25 ml of thionyl chloride, with an intense evolution of gas occurring. After being stirred for one hour at 50°, the mixture is concentrated by evaporation in vacuo. The solid residue is triturated with petroleum ether to obtain 27.4 g (95% of theory) of the above compound in the form of light-yellow crystals, m.p. 95°-96°.
後処理
- concentrationthe mixture is concentrated by evaporation in vacuo
- customThe solid residue is triturated with petroleum ether
- customto obtain 27.4 g (95% of theory) of the above compound in the form of light-yellow crystals, m.p. 95°-96°
出典と根拠
- ORDレコード
- ord-30c445072e804ef296d7dc3539a5c523
- 出典データセット
- uspto-grants-1979_02
- 特許番号
- US04138243
反応ノート
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