Sodium Hydroxide → 3-Chloro-5-(3,5-dimethylpiperidinosulfonyl)benzoic Acid

HRID 1390515ノート

反応式

HRID 1390515 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([S:11](Cl)(=[O:13])=[O:12])[CH:10]=1)[C:5]([OH:7])=[O:6].Cl.[CH3:16][CH:17]1[CH2:22][CH:21]([CH3:23])[CH2:20][NH:19][CH2:18]1.[OH-].[Na+]>O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([S:11]([N:19]2[CH2:20][CH:21]([CH3:23])[CH2:22][CH:17]([CH3:16])[CH2:18]2)(=[O:13])=[O:12])[CH:10]=1)[C:5]([OH:7])=[O:6]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 38612753-Chloro-5-(chlorosulfonyl)benzoic acidHCID 22670446HCID 22670446、化合物

生成物 1

HCID 205059493-Chloro-5-(3,5-dimethylpiperidinosulfonyl)benzoic Acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

3-Chloro-5-chlorosulfonylbenzoic acid (770 mg., 3 m moles) is added to a solution of 3,5-dimethylpiperidine hydrochloride in 30 ml. of water followed by the portionwise addition of 12 ml. of 1N sodium hydroxide solution with stirring. After 1.5 hrs. at room temperature the reaction mixture is filtered and the filtrate acidified with 12N hydrochloric acid. The product, 600 mg., m.p. 226°-331° C., is recrystallized from acetone-hexane, 390 mg., m.p. 232.5°-234° C.

後処理

  1. filtrationat room temperature the reaction mixture is filtered
  2. custom, m.p. 226°-331° C., is recrystallized from acetone-hexane, 390 mg

出典と根拠

ORDレコード
ord-b543db0f0d834cb79f86a7176811b01f
出典データセット
uspto-grants-1979_02
特許番号
US04138399

反応ノート

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