Diethyl Ether → 3-Amino-4,5-dicarbomethoxy-2-(p-chlorophenyl)pyrrole hydrochloride
反応式
[NH2:1][CH:2]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)[C:3]#[N:4].[C:12]([C:16]#[C:17][C:18]([O:20][CH3:21])=[O:19])([O:14][CH3:15])=[O:13].C(OCC)C>CO.C(OCC)C>[ClH:11].[NH2:4][C:3]1[C:16]([C:12]([O:14][CH3:15])=[O:13])=[C:17]([C:18]([O:20][CH3:21])=[O:19])[NH:1][C:2]=1[C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1参加物
5
実験手順
Starting from 2-amino-2-(p-chlorophenyl)acetonitrile and dicarbomethoxyacetylene, the open-chain intermediate compound is obtained, m.p. 74°-76° C. (from diethyl ether). The title compound is obtained in a 48% overall yield, m.p. 216°-8° C. (from methanol/diethyl ether).
後処理
- customthe open-chain intermediate compound is obtained
出典と根拠
- ORDレコード
- ord-292b2b46d51646f484578321631f1650
- 出典データセット
- uspto-grants-1979_02
- 特許番号
- US04140696
反応ノート
読み込み中…