Water → [2-(3-Hydroxypropyl)phenyl]acetic acid

HRID 1391188ノート

反応式

HRID 1391188 の反応式
[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][C:12]#N.[OH-:14].[Na+].[OH2:16]>C(O)C>[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][C:12]([OH:16])=[O:14]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 22645929[2-(3-Hydroxypropyl)phenyl]acetonitrile

生成物 1

HCID 20386052[2-(3-Hydroxypropyl)phenyl]acetic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of [2-(3-hydroxypropyl)phenyl]acetonitrile (52.5 g., 0.30 mole) and sodium hydroxide (40 g., 1.0 mole) in water (200 ml.) and ethanol (600 ml.) is heated at reflux for 18 hours. The solution is concentrated in vacuo to about half-volume. Water (600 ml.) is added and the resulting solution is acidified with 6N hydrochloric acid. The precipitated product acid is taken up in ether, washed with water, and dried over magnesium sulfate. The ether is evaporated in vacuo to afford [2-(3-hydroxypropyl)phenyl]acetic acid.

後処理

  1. temperatureat reflux for 18 hours
  2. concentrationThe solution is concentrated in vacuo to about half-volume
  3. additionWater (600 ml.) is added
  4. washwashed with water
  5. dry with materialdried over magnesium sulfate
  6. customThe ether is evaporated in vacuo

出典と根拠

ORDレコード
ord-45491a9742ad465885dc7c57969f5093
出典データセット
uspto-grants-1979_02
特許番号
US04140861

反応ノート

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