Isopropylamine → HCID 10410596、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:31]=[CH:30][C:13]([O:14][CH2:15][CH2:16][NH:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([CH2:25][NH:26][CH2:27][CH2:28]C)=[CH:21][CH:20]=3)=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[CH:32](N)(C)C>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]#[C:9][C:10]2[CH:11]=[CH:12][C:13]([O:14][CH2:15][CH2:16][NH:17][CH2:18][C:19]3[CH:20]=[CH:21][C:22]([CH2:25][NH:26][CH:27]([CH3:28])[CH3:32])=[CH:23][CH:24]=3)=[CH:30][CH:31]=2)=[CH:6][CH:7]=1参加物
3
実験手順
Compound 4 was synthesized using the procedure described for Compound 2 except that isopropylamine was used in the last reductive amination step. Compound 4 was obtained as a yellow gum. MS 433; 1H NMR (CDCl3) δ 4.10 (t, 2H), 3.86 (d, 2H, becomes singlet with D2O exchange), 2.80 (m, 1 H), 1.09 (d, 6H).
後処理
- customCompound 4 was synthesized
出典と根拠
- ORDレコード
- ord-bf7e2316772041a4a1a98626d6839158
- 出典データセット
- uspto-grants-2008_03