Thionyl Chloride → 2-Chloro-1-methyl-5-nitro-1H-benzimidazole

HRID 1391544ノート

反応式

HRID 1391544 の反応式
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:5]=2[NH:4][C:3]1=S.O=S(Cl)[Cl:17]>>[Cl:17][C:3]1[N:2]([CH3:1])[C:6]2[CH:7]=[CH:8][C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:5]=2[N:4]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 21226931HCID 21226931、化合物

生成物 1

HCID 108223912-Chloro-1-methyl-5-nitro-1H-benzimidazole

実験手順

The compound 1-Methyl-5-nitro-1,3-dihydro-benzoimidazole-2-thione (5.8 g, 27.9 mmol) was heated to reflux with SOCl2 (30 ml) overnight. The reaction mixture was cooled to room temperature and poured into 300 ml of ice water and extracted with CH2Cl2. The organic layers was washed with 10% NaHCO3 water solution, brine, dried over Na2SO4 and concentrated to give the title compound as a yellow solid. MS (ESI) m/z=212 [M+H].

後処理

  1. extractionextracted with CH2Cl2
  2. washThe organic layers was washed with 10% NaHCO3 water solution, brine
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-95436be09f304e759035941098a0666d
出典データセット
uspto-grants-2008_03
特許番号
US07338959B2

反応ノート

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