Sodium Hydroxide → 1-methyl-5-nitro-1H-benzimidazol-2-amine

HRID 1391547ノート

反応式

HRID 1391547 の反応式
[CH3:1][NH:2][C:3]1[C:4]([NH2:12])=[CH:5][C:6]([N+:9]([O-:11])=[O:10])=[CH:7][CH:8]=1.[N-:13]=[C:14]=S.[Br-].[OH-].[Na+]>CO>[CH3:1][N:2]1[C:3]2[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:4]=2[N:12]=[C:14]1[NH2:13]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 34200251-N-methyl-4-nitrobenzene-1,2-diamineHCID 178419725HCID 178419725、化合物

生成物 1

HCID 450786361-methyl-5-nitro-1H-benzimidazol-2-amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a solution of N1-Methyl-4-nitro-benzene-1,2-diamine (5 g, 30 mmol) in MeOH was added bromide isothiocyanate (4.4 g, 42 mmol) and the mixture was stirred at rt. After 16 h. 6N NaOH solution was added to the reaction mixture until Ph˜10 and MeOH was then removed in vacuo. H2O was added and the solid was filtered and dried to give the title compound as an off white solid (5.2 g, 90%). MS (ESI) m/z=193 [M+H]+.

後処理

  1. customwas then removed in vacuo
  2. additionH2O was added
  3. filtrationthe solid was filtered
  4. customdried

出典と根拠

ORDレコード
ord-b2b71a75ab654a4c9e9d2aba2c7a4fee
出典データセット
uspto-grants-2008_03
特許番号
US07338959B2

反応ノート

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