Hydrazine → 3-(Morpholine-4-sulfonyl)aniline
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([S:10]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)([O-])=O.NN>[Pd].C(O)C>[N:13]1([S:10]([C:6]2[CH:5]=[C:4]([NH2:1])[CH:9]=[CH:8][CH:7]=2)(=[O:12])=[O:11])[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1参加物
5
反応条件
- 温度
- 0 °C
実験手順
4-(3-Nitro-benzenesulfonyl)-morpholine (5.9 g, 21.7 mmol) was combined with 10% palladium on carbon (1 g), ethanol (60 mL), and hydrazine (5 mL) and heated at reflux for 18 h. The solution was filtered through celite, concentrated, and cooled to 0° C. Product precipitated out an colorless crystal (4.7 g, 89%). MS (ESI) m/z=243 [M+H]+.
後処理
- temperatureheated
- temperatureat reflux for 18 h
- filtrationThe solution was filtered through celite,
- concentrationconcentrated
- customProduct precipitated out an colorless crystal (4.7 g, 89%)
出典と根拠
- ORDレコード
- ord-b08f1faa142846b09fe91bc68d0d6f65
- 出典データセット
- uspto-grants-2008_03
- 特許番号
- US07338959B2
反応ノート
読み込み中…