反応式
S(Cl)([Cl:3])=O.[CH3:5][C:6]1[N:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:11][C:7]=1[C:8](O)=[O:9]>C1(C)C=CC=CC=1>[CH3:5][C:6]1[C:7]([C:8]([Cl:3])=[O:9])=[CH:11][CH:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[N:14]=1参加物
4
実験手順
Thionyl chloride (4.35 g, 36.5 mmol) was added to a mixture of 2-methyl-6-trifluoromethyl nicotinic acid (5.00 g, 24.4 mmol) in 75 mL of toluene and the mixture was heated at reflux for 3 hours. The reaction was cooled to room temperature and the solvent was removed under reduced pressure. Excess thionyl chloride was removed by azeotrope with toluene. The resultant acid chloride was used as is in Example 4, Step B.
後処理
- temperaturethe mixture was heated
- temperatureat reflux for 3 hours
- customthe solvent was removed under reduced pressure
- customExcess thionyl chloride was removed by azeotrope with toluene
出典と根拠
- ORDレコード
- ord-292669329be041e58347e6c40fe1f5c5
- 出典データセット
- uspto-grants-2008_03
- 特許番号
- US07338978B2
関連ノート
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