1-[4-(4-Nitro-phenyl)-butyl]-1H-[1,2,3]triazole → 4-(4-[1,2,3]Triazol-1-yl-butyl)-phenylamine

HRID 1392221ノート

反応式

HRID 1392221 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH2:12][CH2:13][N:14]2[CH:18]=[CH:17][N:16]=[N:15]2)=[CH:6][CH:5]=1)([O-])=O>CO.C1COCC1.[Pd]>[N:14]1([CH2:13][CH2:12][CH2:11][CH2:10][C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=2)[CH:18]=[CH:17][N:16]=[N:15]1

参加物

4

反応物 1

HCID 184535201-[4-(4-Nitro-phenyl)-butyl]-1H-[1,2,3]triazole

生成物 1

HCID 184535324-(4-[1,2,3]Triazol-1-yl-butyl)-phenylamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

1-[4-(4-Nitro-phenyl)-butyl]-1H-[1,2,3]triazole (2.89 g, 11.74 mmol) is hydrogenated in a mixture of methanol/THF (1:1, 50 ml) in the presence of palladium on charcoal (10%, 0.5 g) for 5 h. After filtration solvents are removed in vacuo yielding 4-(4-[1,2,3]triazol-1-yl-butyl)-phenylamine as a yellow gum. Yield 2.03 g (80%)

後処理

  1. filtrationAfter filtration solvents
  2. customare removed in vacuo

出典と根拠

ORDレコード
ord-d91525802730468c915c1d18f2896f27
出典データセット
uspto-grants-2008_03
特許番号
US07342030B2

反応ノート

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