m-Chloroperbenzoic acid → HCID 69313017、化合物
反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH:12]=[CH:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].ClC1C=CC=C([C:21](OO)=[O:22])C=1>ClCCl>[O:22]=[C:21]1[CH:10]2[CH:11]1[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[CH2:9]2参加物
4
実験手順
To the solution of N-tert-butoxycarbonyl-1,2,3,6-tetrahydropyridine (110 g, 0.60 mol) obtained in Step 1 in 300 ml of dichloromethane, was added 3-chloroperbenzoic acid (m-CPBA; 311 g, 1.80 mol). The reaction mixture was stirred overnight at room temperature and filtered to remove benzoic acid produced. The resulting filtrate was washed with a saturated potassium carbonate solution, brine and distilled water. The resulting organic layer was dried and concentrated on magnesium sulfate to give the titled compound (180.6 g).
後処理
- filtrationfiltered
- customto remove benzoic acid
- customproduced
- washThe resulting filtrate was washed with a saturated potassium carbonate solution, brine
- distillationdistilled water
- customThe resulting organic layer was dried
- concentrationconcentrated on magnesium sulfate
出典と根拠
- ORDレコード
- ord-cd642a4907304a7082f65317d3ec0807
- 出典データセット
- uspto-grants-2008_03
- 特許番号
- US07342027B2
反応ノート
読み込み中…