Sodium Hydroxide → 1-[(2-Furanylcarbonyl)amino]cyclohexanecarboxylic acid

HRID 1392409

反応式

HRID 1392409 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([NH:8][C:9]1([C:15]([O:17]C)=[O:16])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)=[O:7].[OH-].[Na+]>CO>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([NH:8][C:9]1([C:15]([OH:17])=[O:16])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)=[O:7]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 17464840methyl 1-[N-(furan-2-ylcarbonyl)amino]-1-cyclohexanecarboxylate

生成物 1

HCID 174552541-[(2-Furanylcarbonyl)amino]cyclohexanecarboxylic acid収率 67.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To the solution of methyl 1-[N-(furan-2-ylcarbonyl)amino]-1-cyclohexanecarboxylate (9.6 g) obtained in Step 1 in 100 ml of methanol, was added 2N-sodium hydroxide solution (50 ml). The reaction mixture was refluxed for 3 hours and concentrated. The resulting residue was diluted with 150 ml of water and washed with 100 ml of diethyl ether. 6N-hydrochloride was added dropwise to the resulting aqueous layer to adjust the pH of the solution to pH 3. The resulting white solid was filtered and dried to give the titled compound (6.1 g).

後処理

  1. temperatureThe reaction mixture was refluxed for 3 hours
  2. concentrationconcentrated
  3. additionThe resulting residue was diluted with 150 ml of water
  4. washwashed with 100 ml of diethyl ether
  5. addition6N-hydrochloride was added dropwise to the resulting aqueous layer
  6. filtrationThe resulting white solid was filtered
  7. customdried

出典と根拠

ORDレコード
ord-799b78f15edb4ce1ac8f00e026c29467
出典データセット
uspto-grants-2008_03
特許番号
US07342027B2

関連ノート

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