Trifluoroacetic acid → (4-Ethylamino-phenoxy)-acetic acid ethyl ester

HRID 1393087ノート

反応式

HRID 1393087 の反応式
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N:13](C(OC(C)(C)C)=O)[CH2:14][CH3:15])=[CH:9][CH:8]=1)[CH3:2].C(O)(C(F)(F)F)=O>>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][CH2:14][CH3:15])=[CH:9][CH:8]=1)[CH3:2]

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 69220753[4-(Tert-butoxycarbonyl-ethyl-amino)-phenoxy]-acetic acid ethyl ester

生成物 1

HCID 69220443(4-Ethylamino-phenoxy)-acetic acid ethyl ester

実験手順

Analogously, to example 1.4, crude [4-(tert-butoxycarbonyl-ethyl-amino)-phenoxy]-acetic acid ethyl ester was deprotected with TFA to give (4-ethylamino-phenoxy)-acetic acid ethyl ester as light brown oil, MS: 224 (MH+).

出典と根拠

ORDレコード
ord-02b31ee3cf3141fa9e93946b2b0e3f07
出典データセット
uspto-grants-2008_03
特許番号
US07345067B2

反応ノート

読み込み中…