Acetone → 3-(Benzylamino)-3-methylbutanoic Acid
反応式
[CH3:1][C:2]([CH3:7])=[CH:3][C:4]([OH:6])=[O:5].[CH2:8]([NH2:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.CC(C)=O>N1C=CC=CC=1>[CH2:8]([NH:15][C:2]([CH3:7])([CH3:1])[CH2:3][C:4]([OH:6])=[O:5])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1参加物
5
反応条件
- 温度
- 120 °C
実験手順
3-Methylcrotonic acid (12.0 g) was dissolved in pyridine (40 ml), and benzyl amine (12.8 g) was added thereto, and the mixture was stirred for 3 hours at 120° C. The reaction mixture was cooled to room temperature, and after acetone was added to the resulting suspension, crystals were collected by filtration and washed. The crystals were dried under reduced pressure to give 3-benzylamino-3-methylbutanoic acid (10.3 g, Y.:42%) as colorless crystals.
後処理
- temperatureThe reaction mixture was cooled to room temperature
- filtrationwere collected by filtration
- washwashed
- customThe crystals were dried under reduced pressure
出典と根拠
- ORDレコード
- ord-a65ca87bd6824b3a80fcd4887b697153
- 出典データセット
- uspto-grants-2008_03
- 特許番号
- US07345180B2
反応ノート
読み込み中…