Trifluoroacetic acid → 1-Methyl-2,3-dihydro-1H-indole-5-carboxylic acid

HRID 1393672

反応式

HRID 1393672 の反応式
C([SiH](CC)CC)C.[CH3:8][N:9]1[C:17]2[C:12](=[CH:13][C:14]([C:18]([OH:20])=[O:19])=[CH:15][CH:16]=2)[CH:11]=[CH:10]1.FC(F)(F)C(O)=O>ClCCl>[CH3:8][N:9]1[C:17]2[C:12](=[CH:13][C:14]([C:18]([OH:20])=[O:19])=[CH:15][CH:16]=2)[CH2:11][CH2:10]1

参加物

5

反応物 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 70156011-Methyl-1H-indole-5-carboxylic acid

生成物 1

HCID 230920021-Methyl-2,3-dihydro-1H-indole-5-carboxylic acid収率 65.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

Dichloromethane (2 ml) and triethylsilane (1 ml) were added to 1-methyl-1H-indole-5-carboxylic acid (100 mg). The mixture was cooled to 0° C., trifluoroacetic acid (1 ml) was added dropwise thereto, and the mixture was warmed to room temperature and stirred for 2 hours. The reaction mixture was concentrated under reduced pressure, and precipitate was collected by filtration. The precipitate was washed with ether and dried under reduced pressure to give the title compound (66 mg, Y.:65%).

後処理

  1. temperaturethe mixture was warmed to room temperature
  2. concentrationThe reaction mixture was concentrated under reduced pressure, and precipitate
  3. filtrationwas collected by filtration
  4. washThe precipitate was washed with ether
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-7ae5d4a85d124e04a59aa672b7dd4228
出典データセット
uspto-grants-2008_03
特許番号
US07345180B2

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