HCID 23092000、化合物 → 1-acetylindoline-5-carboxylic acid

HRID 1393674ノート

反応式

HRID 1393674 の反応式
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([O:15]CC3C=CC=CC=3)=[O:14])=[CH:10][CH:11]=2)[CH:6]=[CH:5]1)(=[O:3])[CH3:2].[H][H]>C(O)C.[Pd]>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([OH:15])=[O:14])=[CH:10][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

参加物

5

反応物 2

HCID 23092000HCID 23092000、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 52955471-acetylindoline-5-carboxylic acid収率 48%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

The benzyl 1-acetyl-1H-indole-5-carboxylate (550 mg) obtained above was suspended in ethanol (9 ml). 10% Palladium on carbon was added thereto, and the mixture was stirred for 16 hours at room temperature in a hydrogen atmosphere. Insoluble matter was removed by filtration, and the filtrate was concentrated under reduced pressure. Precipitated crystals were collected by filtration, washed with ether and dried under reduced pressure to give the title compound (180 mg, Y.:48%).

後処理

  1. customInsoluble matter was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customPrecipitated crystals
  4. filtrationwere collected by filtration
  5. washwashed with ether
  6. customdried under reduced pressure

出典と根拠

ORDレコード
ord-5a12ce0a24374569b20aba7653d7cafe
出典データセット
uspto-grants-2008_03
特許番号
US07345180B2

反応ノート

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