HCID 23091904、化合物 → 1-(2,2-Dimethylpropionyl)-1H-indole-5-carboxylic acid
反応式
[CH3:1][C:2]([CH3:25])([CH3:24])[C:3]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([O:16]CC3C=CC=CC=3)=[O:15])=[CH:11][CH:12]=2)[CH:7]=[CH:6]1)=[O:4].[H][H]>C(O)C.[Pd]>[CH3:1][C:2]([CH3:25])([CH3:24])[C:3]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([OH:16])=[O:15])=[CH:11][CH:12]=2)[CH:7]=[CH:6]1)=[O:4]参加物
5
実験手順
The benzyl 1-(2,2-dimethylpropionyl)-1H-indole-5-carboxylate (220 mg) obtained above was dissolved in ethanol, and 5% palladium on carbon (44 mg) was added thereto and stirred overnight at room temperature in a hydrogen atmosphere. Insoluble matter was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (140 mg, Y.:86%).
後処理
- customInsoluble matter was removed by filtration
- concentrationthe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-fc52fc0792604ff2b7098bed61d5828b
- 出典データセット
- uspto-grants-2008_03
- 特許番号
- US07345180B2
反応ノート
読み込み中…