Chlorosuccinimide → HCID 22185276、化合物
反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:15]=1[NH:14][C:13]1[CH:12]=[N:11][CH:10]=[CH:9][C:8]2=1.[Cl:16]N1C(=O)CCC1=O>C1COCC1>[Cl:16][C:4]1[C:3]([O:2][CH3:1])=[C:15]2[C:7]([C:8]3[CH:9]=[CH:10][N:11]=[CH:12][C:13]=3[NH:14]2)=[CH:6][CH:5]=1参加物
4
実験手順
To a mixture of 8-methoxy-β-carboline (1.0 g, 5 mmol) in THF (100 ml) was added N-chlorosuccinimide (0.70 g, 5.2 mmol). The reaction was stirred at RT for 4 h before concentrating and washing the residue with 1:1:1 mixture of 10% Na2CO3, hexane, and EtOAc (400 ml). The resulting residue was triturated with xylenes to provide 677 mg of 7-chloro-8-methoxy-β-carboline.
後処理
- concentrationbefore concentrating
- washwashing the residue
- additionwith 1:1:1 mixture of 10% Na2CO3, hexane, and EtOAc (400 ml)
- customThe resulting residue was triturated with xylenes
出典と根拠
- ORDレコード
- ord-1f8e8f4fefd34f9cb5b93116568c0ebd
- 出典データセット
- uspto-grants-2008_03
- 特許番号
- US07348336B2
反応ノート
読み込み中…