HCID 57942920、化合物 → HCID 22461189、化合物
反応式
[C:1]([O:5][C:6]([N:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-])=O)[CH:14]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pt]>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([NH2:19])[CH:14]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]参加物
4
実験手順
The product of Step 1 (7.5 g, 26.01 mmol), was dissolved in ethanol (125 ml), and treated with 5 wt % Platinum on charcoal (750 mg), and stirred under 1 atm of H2 for 4 days. The reaction was filtered and the filtrate evaporated in vacuo. The residue was purified by silica gel chromatography eluting with a mixture of ether/dichloromethane (5:95) to afford the title compound (4.2 g, 62%); MS (ES+) m/e 263 [M+H]+.
後処理
- filtrationThe reaction was filtered
- customthe filtrate evaporated in vacuo
- customThe residue was purified by silica gel chromatography
- washeluting with a mixture of ether/dichloromethane (5:95)
出典と根拠
- ORDレコード
- ord-ab77cf7488b847bd8c7d538b15816fc2
- 出典データセット
- uspto-grants-2008_03
- 特許番号
- US07348339B2
反応ノート
読み込み中…